Liver Systems Medicine

striving to develop non-invasive methods for diagnosing and treating NAFLD by combining mathematical modeling and biological research.

Welcome to the LiSyM Network

Liver Systems Medicine, or LiSyM, is a multidisciplinary research network, in which molecular and cell biologists, clinical researchers, pharmacologists and experts in mathematical modeling examine the liver in its entirety.
They want to answer questions about the origin and progression of the metabolic liver disease non-alcoholic fatty liver disease (NAFLD). What initiates NAFLD? How does it develop? How can we improve diagnosis and treatment? More about our work

In LiSyM, 37 research groups at 23 scientific centers and institutions located around Germany have joined forces to tackle some of the most complex problems of the human body. More about us

LiSyM Research

Research focuses on the four key, yet overlapping themes of the pillars. Four junior groups also address specific research topics.

Early Metabolic Injury

When does a fatty liver actually develop a disorder?

Chronic Liver Disease Progression

When connective tissue replaces functioning liver cells

Regeneration and Repair in Acute-on-Chronic Liver Failure (ACLF)

Liver failure after a long illness: Can it be prevented? Can the liver recover?

Liver Function Diagnostics

Develops computer-based diagnostic tools to help detect and assess changed liver functions early.


The Holy Grail of Systems Biology

19 February 2020
LiSyM director Professor Dr. med. Peter Jansen believes that mathematical models are indispensable for the research of biological systems.
Human bodies are complex biological systems, with countless reactions taking place in every cell. These reactions are sometimes interconnected or have an impact on further processes. Furthermore, cells, tissue, and organs are closely connected. Professor Dr. med. Peter Jansen, director of the LiSyM research network, believes that the research of systems like these, which consist of multilayered processes, interactions, and dependencies, needs mathematical models. Only models that simulate biological systems on computers make it possible to assemble the existing mass of heterogeneous data into dynamic reproductions in a meaningful way. Mathematical models enable systems researchers to deliver results more quickly and successfully. The idea that digital computers can play an essential role in this research is older than the machines themselves.
Read the article

Better diagnosis of NAFLD with 3D model of human liver tissue

11 December 2019
LiSyM researchers create geometrical and functional liver model for improved diagnosis of non-alcoholic fatty liver disease.
In collaboration with international researchers, members of the Liver Systems Medicine research network have developed the technology and knowledge to generate 3D geometrical and functional models of human liver tissue at different stages of non-alcoholic fatty liver disease, NAFLD. With these high definition models, cellular and tissue markers can be quantified to define how far NAFLD has progressed in individual patients and thereby improve medical diagnoses markedly.
To press release

SBMC 2020

The LiSyM network continues to organize the biennial SBMC Conference. In 2020 the 8th SBMC Conference will take place in Heidelberg.

Visit the SBMC 2020 website

Research with liver tissue has a long tradition and has been the basis of the discipline of biochemistry. Over the years this research has yielded a wealth of stored quantifiable data. In Systems Medicine these data are re-used to integrate with new data as to develop multi-scale computational models that help in understanding the complexity of metabolism and its derangement in human diseases.
This should lead to a more personalised type of medicine, earlier diagnosis and new therapies

Peter Jansen